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Article

miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway.

Clinical science (London, England : 1979) - 17 Apr 2020

Fan Junqiang, Xu Guanxin, Chang Zhibo, Zhu Ling, Yao Jie

Abstract excerpt

It has been generally believed that cancer-associated fibroblasts (CAFs) have the ability to increase the process of tumor angiogenesis. However, the potential mechanisms by which cancer-derived exosomes in lung cancer (LC) remains to be investigated. LC-derived exosomes were administrated to NIH/3T3 cells. A variety of experiments were conducted to investigate the proangiogenic factors of CAFs, including Western...

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PMID: 32219336
DOI: 10.1042/CS20200039

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