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Article

Identification of injury and shock driven effects on ex vivo platelet aggregometry: A cautionary tale of phenotyping.

The journal of trauma and acute care surgery - 1 Jul 2020

Starr Nichole E, Matthay Zachary A, Fields Alexander T, Nunez-Garcia Brenda, Callcut Rachael A, Cohen Mitchell J, Kornblith Lucy Zumwinkle

Abstract excerpt

BACKGROUND: Platelet behavior in trauma-induced coagulopathy is poorly understood. Injured patients have impaired platelet aggregation (dysfunction) in ex vivo agonist-stimulated platelet aggregometry (PA). However, PA assumes that platelets are inactivated before ex vivo stimulated aggregation, which may be altered by injury. We hypothesized that following trauma, platelet aggregation (area under the curve) is...

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Identifiers

PMID: 32218020
DOI: 10.1097/TA.0000000000002707
PMCID: PMC7386285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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