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Metabolic reprogram associated with epithelial-mesenchymal transition in tumor progression and metastasis

3 Oct 2019

Abstract excerpt

Epithelial-mesenchymal Transition (EMT) is a de-differentiation program that imparts tumor cells with the phenotypic and cellular plasticity required for drug resistance, metastasis, and recurrence. This dynamic and reversible events is governed by a network of EMT-transcription factors (EMT-TFs) through epigenetic regulation. Many chromatin modifying-enzymes utilize metabolic intermediates as cofactors or...

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PMID: 32215287
DOI: 10.1016/j.gendis.2019.09.012

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