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Article

Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV.

Journal of the Royal Society, Interface - 1 Mar 2020

Kreger Jesse, Komarova Natalia L, Wodarz Dominik

Abstract excerpt

Recombination in HIV infection can impact virus evolution in vivo in complex ways, as has been shown both experimentally and mathematically. The effect of free virus versus synaptic, cell-to-cell transmission on the evolution of double mutants, however, has not been investigated. Here, we do so by using a stochastic agent-based model. Consistent with data, we assume spatial constraints for synaptic but not for...

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Identifiers

PMID: 32208824
DOI: 10.1098/rsif.2019.0832
PMCID: PMC7115232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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