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Article

Quantitative Structure-Activity Relationship (QSAR) Studies for the Inhibition of MAOs.

Combinatorial chemistry & high throughput screening - 1 Jan 2020

Ramesh Muthusamy, Muthuraman Arunachalam

Abstract excerpt

Monoamine oxidases are the crucial drug targets for the treatment of neurodegenerative disorders like depression, Parkinson's disease, and Alzheimer's disease. The enzymes catalyze the oxidative deamination of several monoamine containing neurotransmitters, i.e. serotonin (5-HT), melatonin, epinephrine, norepinephrine, phenylethylamine, benzylamine, dopamine, tyramine, etc. The oxidative reaction of monoamine...

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PMID: 32208114
DOI: 10.2174/1386207323666200324173231

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