Article
Differential regulation of antagonistic pleiotropy in synthetic and natural populations suggests its role in adaptation.
G3 (Bethesda, Md.) - 23 Feb 2015
Yadav Anupama, Radhakrishnan Aparna, Bhanot Gyan, Sinha Himanshu
Abstract excerpt
Antagonistic pleiotropy (AP), the ability of a gene to show opposing effects in different phenotypes, has been identified in various life history traits and complex disorders, indicating its fundamental role in balancing fitness over the course of evolution. It is intuitive that natural selection might maintain AP to allow organisms phenotypic flexibility in different environments. However, despite several...
Topics
- Adaptation, Physiological
- Chromosome Mapping
- Cyclic AMP-Dependent Protein Kinases
- Epistasis, Genetic
- Gene Deletion
- Gene-Environment Interaction
- Genetic Association Studies
- Genetic Pleiotropy
- Genetics, Population
- Phenotype
- Quantitative Trait Loci
- Recombination, Genetic
- Saccharomyces cerevisiae