Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis.

BioMed research international - 1 Jan 2020

Zmorzyński Szymon, Wojcierowska-Litwin Magdalena, Kowal Małgorzata, Michalska-Jakubus Małgorzata, Styk Wojciech, Filip Agata Anna, Walecka Irena, Krasowska Dorota

Abstract excerpt

Introduction. NOTCH pathway and TP53 protein are involved in the development of fibrosis and autoimmune disorders, respectively. The aim of this study was to evaluate the role of single nucleotide polymorphisms (SNPs) of NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of systemic sclerosis (SSc), and clinical profile of SSc patient, particularly with lung involvement...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Lung Diseases, Interstitial

Share to Receptor, Notch3

Share to Scleroderma, Systemic

Share to Tumor Suppressor Protein p53

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 32185220
DOI: 10.1155/2020/8465971
PMCID: PMC7060860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis.PMID 32185220Read ↗

Genetic Susceptibility to Systemic Sclerosis in the Greek-Cypriot Population: A Pilot Study.Semantic proximity Read ↗

The genetics of systemic sclerosis.Semantic proximity Read ↗

Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.Semantic proximity Read ↗

BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians.Semantic proximity Read ↗

A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.Semantic proximity Read ↗

Association study between the TP53 Rs1042522G/C polymorphism and susceptibility to systemic lupus erythematosus in a Chinese Han population.Semantic proximity Read ↗

The FAS -670A>G polymorphism influences susceptibility to systemic sclerosis phenotypes.Semantic proximity Read ↗

Preliminary observations on ANGPT1 and ANGPT2 polymorphisms in systemic sclerosis: ANGPT2 rs2442598 and rs3739390 are associated with disease susceptibility and diffuse disease subtype.Semantic proximity Read ↗

Polymorphisms in STAT4 and IRF5 increase the risk of systemic sclerosis: a meta-analysis.Semantic proximity Read ↗

[The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study].Semantic proximity Read ↗

Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis.Semantic proximity Read ↗

Association of TAP1 and TAP2 with systemic sclerosis in Japanese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.