Article
Combined 5-hydroxymethylcytosine content of human leucocyte antigen-B and human leucocyte antigen-DQB1 as novel biomarker for anti-tuberculosis drug-induced liver injury.
Basic & clinical pharmacology & toxicology - 1 Sept 2020
Li Yuhong, Ren Qi, Wu Dongxue, Zhang Mi, Wang Xue, Zhu Hanyu, Sun Shufeng, Feng Fumin
Abstract excerpt
This study investigated the diagnostic value of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) contents of human leucocyte antigen (HLA)-B and HLA-DQB1 in anti-tuberculosis drug-induced liver injury (ADLI). In total, 110 ADLI patients and 120 patients without ADLI controls were enrolled. Enzyme-linked immunosorbent assay (ELISA) was used to detect the 5-mC and 5-hmC content in DNA from peripheral...
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