Article
Association between polymorphisms in HLA-A, HLA-B, HLA-DR, and DQ genes from gastric cancer and duodenal ulcer patients and cagL among cagA-positive Helicobacter pylori strains: The first study in a Turkish population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2020
Kocak Banu Tufan, Saribas Suat, Demiryas Suleyman, Yilmaz Erkan, Uysal Omer, Kepil Nuray, Demirci Mehmet, Dınc Harika Oyku, Akkus Seher, Gülergün Reyhan, Gareayaghi Nesrin, Dağdeviren Hüseyin Emre, Ozbey Dogukan, Dağ Hamit Harun, Tokman Hrisi Bahar, Tasci Ihsan, Kocazeybek Bekir
Abstract excerpt
Colonization of the human gastric mucosa by H. pylori may cause peptic and duodenal ulcers (DUs), gastric lymphomas, and gastric cancers. The cagL gene is a component of cag T4SS and is involved in cagA translocation into host. An association between the risk of gastric cancer and the type of HLA class II (DR and/or DQ) was suggested in different populations. The aim of this study was to investigate, the clinical...
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