Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis.

Molecular carcinogenesis - 1 Oct 2011

Yeh Yi-Chun, Chang Wei-Lun, Yang Hsiao-Bai, Cheng Hsiu-Chi, Wu Jiunn-Jung, Sheu Bor-Shyang

Abstract excerpt

We tested whether cagL amino acid sequence polymorphisms of Helicobacter pylori correlated to clinico-histological outcomes and gastric α5β1 integrin expressions. One hundred forty five patients with H. pylori infection and 47 noninfected controls were enrolled to check gastric integrin α5β1 intensities topographically. The collected isolates were screened for cagL-genotype by polymerase chain reaction (PCR), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastric Mucosa
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Host-Pathogen Interactions

Share to Stomach

Share to Stomach Neoplasms

Share to Tyrosine

Source

Identifiers

PMID: 21374738
DOI: 10.1002/mc.20753

Genes

GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis.PMID 21374738Read ↗

Helicobacter pylori cagL amino acid polymorphisms and its association with gastroduodenal diseases.Semantic proximity Read ↗

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancerSemantic proximity Read ↗

Helicobacter pylori cagL amino acid polymorphism D58E59 pave the way toward peptic ulcer disease while N58E59 is associated with gastric cancer in north of Iran.Semantic proximity Read ↗

The Relationship between Gastroduodenal Pathologies and Helicobacter pylori cagL (Cytotoxin-Associated Gene L) Polymorphism.Semantic proximity Read ↗

H. pylori CagL-Y58/E59 prime higher integrin α5β1 in adverse pH condition to enhance hypochlorhydria vicious cycle for gastric carcinogenesis.Semantic proximity Read ↗

Genetic diversity and amino acid sequence polymorphism in Helicobacter pylori CagL hypervariable motif and its association with virulence markers and gastroduodenal diseasesSemantic proximity Read ↗

Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomesSemantic proximity Read ↗

Helicobacter pylori CagL Y58/E59 mutation turns-off type IV secretion-dependent delivery of CagA into host cells.Semantic proximity Read ↗

Preservation of Helicobacter pylori CagA Translocation and Host Cell Proinflammatory Responses in the Face of CagL Hypervariability at Amino Acid Residues 58/59.Semantic proximity Read ↗

Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoproteinSemantic proximity Read ↗

Geographic differences and the role of cagA gene in gastroduodenal diseases associated with Helicobacter pylori infection.Semantic proximity Read ↗

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.