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Investigating Associations between HLA-DR Genotype, H. pylori Infection, and Anti-CagA IgA Seropositivity in a Turkish Gastritis Cohort.

Genes - 6 Mar 2024

Karataş Lokman, Tatar Zeynep, James Eddie A, Colakogullari Mukaddes

Abstract excerpt

Helicobacter pylori (H. pylori) is associated with gastric inflammation and mucosal antibodies against its cytotoxin-associated gene A (CagA) are protective. Vaccine-elicited immunity against H. pylori requires MHC class II expression, indicating that CD4+ T cells are protective. We hypothesized that the HLA-DR genotypes in human populations include protective alleles that more effectively bind immunogenic CagA...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38540398
DOI: 10.3390/genes15030339
PMCID: PMC10969812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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