Article
Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.
Cancer research - 15 Sept 2008
Tran Melissa A, Gowda Raghavendra, Sharma Arati, Park Eun-Joo, Adair James, Kester Mark, Smith Nadine Barrie, Robertson Gavin P
Abstract excerpt
Most events promoting early melanoma development are yet to be identified, but deregulation of the B-Raf and Akt3 signaling cascades is an important regulator of this process. Approximately 90% of normal moles and approximately 60% of early invasive cutaneous melanomas contain a T1799A B-Raf mutation ((V600E)B-Raf), leading to 10 times higher enzyme activity and constitutive activation of the mitogen-activated...
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