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Analysis of Anti-RNA Polymerase III Antibody-positive Systemic Sclerosis and Altered GPATCH2L and CTNND2 Expression in Scleroderma Renal Crisis

15 Mar 2020

Abstract excerpt

Objective Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc) strongly associated with anti-RNA polymerase III antibody (ARA) autoantibodies. We investigated genetic susceptibility and altered protein expression in renal biopsy specimens in ARA-positive patients with SRC. Methods ARA-positive patients (n = 99) with at least 5 years’ follow-up (49% with a history of SRC)...

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PMID: 32173657
DOI: 10.3899/jrheum.190945

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