Article
FKBP5 haplotypes and PTSD modulate the resting-state brain activity in Han Chinese adults who lost their only child.
Translational psychiatry - 13 Mar 2020
Qi Rongfeng, Luo Yifeng, Zhang Li, Weng Yifei, Surento Wesley, Jahanshad Neda, Xu Qiang, Yin Yan, Li Lingjiang, Cao Zhihong, Thompson Paul M, Lu Guang Ming
Abstract excerpt
The stress-related gene FKBP5 has been related to dysregulated glucocorticoid receptor (GR) signaling, showing increased GR sensitivity in trauma-exposed subjects with post-traumatic stress disorder (PTSD) but not in those without PTSD. However, the neural mechanism underlying the effects of FKBP5 remains poorly understood. Two hundred and thirty-seven Han Chinese adults who had lost their only child were...
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