Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma.

doi:10.1016/j.jcmgh.2020.02.009

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Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2020

Hashiba Tomomi, Yamashita Taro, Okada Hikari, Nio Kouki, Hayashi Takehiro, Asahina Yoshiro, Hayashi Tomoyuki, Terashima Takeshi, Iida Noriho, Takatori Hajime, Shimakami Tetsuro, Kawaguchi Kazunori, Arai Kuniaki, Sakai Yoshio, Yamashita Tatsuya, Mizukoshi Eishiro, Takamura Hiroyuki, Ohta Tetsuo, Honda Masao, Kaneko Shuichi

Abstract excerpt

BACKGROUND & AIMS: Sorafenib is a multireceptor tyrosine kinase inhibitor that can prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Although most HCC patients who receive sorafenib ultimately show disease progression, it still is unclear whether and how HCC cells acquire chemoresistance during sorafenib treatment in human beings. METHODS: We analyzed surgically resected HCC...

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PMID: 32169577
DOI: 10.1016/j.jcmgh.2020.02.009
PMCID: PMC7305345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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