Article
Genotype-guided warfarin therapy: Still of only questionable value two decades on.
Journal of clinical pharmacy and therapeutics - 1 Jun 2020
Shah Rashmi R
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Despite an apparently sound pharmacological basis, clinical studies of genotype-guided warfarin dosing have yielded mixed and conflicting results, leading to reluctance in its clinical implementation. The objective of this critique is to re-evaluate key warfarin pharmacogenetic studies with a view to explaining why this may be so. METHODS: Major widely-cited warfarin pharmacogenetic...
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