Article
Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity.
G3 (Bethesda, Md.) - 4 May 2020
Dimitriadou Agapi, Chatzianastasi Nasia, Zacharaki Panagiota I, O'Connor MaryJane, Goldsmith Samuel L, O'Connor Michael B, Consoulas Christos, Newfeld Stuart J
Abstract excerpt
The CORL family of CNS-specific proteins share a Smad-binding region with mammalian SnoN and c-Ski protooncogenes. In this family Drosophila CORL has two mouse and two human relatives. Roles for the mouse and human CORL proteins are largely unknown. Based on genome-wide association studies linking the human CORL proteins Fussel15 and Fussel18 with ataxia, we tested the hypothesis that dCORL mutations will cause...
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