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Circulating tumor DNA (ctDNA) is not a good proxy for liquid biopsies of tumor tissues for early detection.

Clinical chemistry and laboratory medicine - 25 Sept 2020

Fiala Clare, Diamandis Eleftherios P

Abstract excerpt

The important conclusion that ctDNA is a mediocre proxy for liquid biopsies of tumor tissues for early detection was reached after new data were published recently in Nature Genetics. These data have shown that most mutations found in ctDNA are not related to tumor tissues but rather to the precancerous condition clonal hematopoiesis. Previously, our group has analyzed the sensitivity of the ctDNA test for early...

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Identifiers

PMID: 32160156
DOI: 10.1515/cclm-2020-0083

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