Article
The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review.
BMC cancer - 23 Oct 2017
Cree Ian A, Uttley Lesley, Buckley Woods Helen, Kikuchi Hugh, Reiman Anne, Harnan Susan, Whiteman Becky L, Philips Sian Taylor, Messenger Michael, Cox Angela, Teare Dawn, Sheils Orla, Shaw Jacqui
Abstract excerpt
BACKGROUND: The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagnose the presence of activating mutations to guide treatment. In 2014, the UK Early Cancer Detection Consortium undertook a systematic mapping review of the literature to identify blood-based...
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