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Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

22 Jul 2016

Abstract excerpt

Cytosolic and organelle-based heat-shock protein (HSP) chaperones ensure proper folding and function of nascent and injured polypeptides to support cell growth. Under conditions of cellular stress, including oncogenic transformation, proteostasis components maintain homeostasis and prevent apoptosis. Although this cancer-relevant function has provided a rationale for therapeutically targeting proteostasis...

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PMID: 27450084
DOI: 10.1073/pnas.1603883113

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