Article
Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.
Developmental biology - 1 Jul 2020
Fulmer Diana, Toomer Katelynn A, Glover Janiece, Guo Lilong, Moore Kelsey, Moore Reece, Stairley Rebecca, Gensemer Cortney, Abrol Sameer, Rumph Mary Kate, Emetu Faith, Lipschutz Joshua H, McDowell Colin, Bian Justin, Wang Christina, Beck Tyler, Wessels Andy, Renault Marie-Ange, Norris Russell A
Abstract excerpt
Non-syndromic mitral valve prolapse (MVP) is the most common heart valve disease affecting 2.4% of the population. Recent studies have identified genetic defects in primary cilia as causative to MVP, although the mechanism of their action is currently unknown. Using a series of gene inactivation approaches, we define a paracrine mechanism by which endocardially-expressed Desert Hedgehog (DHH) activates primary...
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