Article
Aneuploidy and recombination in the human preimplantation embryo. Copy number variation analysis and genome-wide polymorphism genotyping.
Reproductive biomedicine online - 1 Apr 2020
Konstantinidis Michalis, Ravichandran Krithika, Gunes Zeynep, Prates Renata, Goodall N-Neka, Roman Bo, Ribustello Lia, Shanmugam Avinash, Colls Pere, Munné Santiago, Wells Dagan
Abstract excerpt
RESEARCH QUESTION: What are the incidence and patterns of meiotic trisomies and recombination separately and in relation to each other at the blastocyst stage via single nucleotide polymorphism genotyping combined with array comparative genomic hybridization. DESIGN: Single nucleotide polymorphism microarrays were carried out on a total of 1442 blastocyst stage embryos derived from 268 fertile couples undergoing...
Topics
- Aneuploidy
- Blastocyst
- DNA Copy Number Variations
- Female
- Genotype
- Humans
- Male
- Meiosis
- Polymorphism, Single Nucleotide
- Pregnancy
- Preimplantation Diagnosis
- Recombination, Genetic