Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.

doi:10.1016/j.ccell.2020.02.003

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Article

Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.

Cancer cell - 16 Mar 2020

Zheng Ze-Yi, Anurag Meenakshi, Lei Jonathan T, Cao Jin, Singh Purba, Peng Jianheng, Kennedy Hilda, Nguyen Nhu-Chau, Chen Yue, Lavere Philip, Li Jing, Du Xin-Hui, Cakar Burcu, Song Wei, Kim Beom-Jun, Shi Jiejun, Seker Sinem, Chan Doug W, Zhao Guo-Qiang, Chen Xi, Banks Kimberly C, Lanman Richard B, Shafaee Maryam Nemati, Zhang Xiang H-F, Vasaikar Suhas, Zhang Bing, Hilsenbeck Susan G, Li Wei, Foulds Charles E, Ellis Matthew J, Chang Eric C

Abstract excerpt

We report that neurofibromin, a tumor suppressor and Ras-GAP (GTPase-activating protein), is also an estrogen receptor-α (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that are functionally independent of GAP activity. GAP activity, in turn, does not affect ER binding. Consequently, neurofibromin depletion causes estradiol hypersensitivity and tamoxifen agonism, explaining the poor...

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Identifiers

PMID: 32142667
DOI: 10.1016/j.ccell.2020.02.003
PMCID: PMC7286719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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