Article
SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.
Clinical epigenetics - 5 Mar 2020
Jiang Yu, Liu Lei, Xiang Qin, He Xiaoqian, Wang Yan, Zhou Dishu, Zou Can, Chen Qian, Peng Mingyu, He Jin, Jiang Xianyao, Xiang Tingxiu, Yang Yucheng
Abstract excerpt
BACKGROUND: Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngeal carcinoma cases remains disappointing. SEPT9 is a methylation-based biomarker approved by the US Food and Drug Administration for colorectal cancer screening and diagnosis. Interestingly,...
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