Article
Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Dec 2013
Liyanarachchi Sandya, Wojcicka Anna, Li Wei, Czetwertynska Malgorzata, Stachlewska Elzbieta, Nagy Rebecca, Hoag Kevin, Wen Bernard, Ploski Rafal, Ringel Matthew D, Kozłowicz-Gudzinska Izabella, Gierlikowski Wojciech, Jazdzewski Krystian, He Huiling, de la Chapelle Albert
Abstract excerpt
BACKGROUND: Two recent genome-wide association studies (GWASs) identified five single nucleotide polymorphisms (SNPs; rs965513, rs944289, rs966423, rs2439302, and rs116909374) associated with papillary thyroid carcinoma (PTC). Each variant showed highly significant but moderate to low disease risk. Here we assessed the cumulative risk and predictive value of the five SNPs. METHODS: We genotyped two cohorts of...
