Article
Disruption of the Burkholderia pseudomallei two-component signal transduction system BbeR-BbeS leads to increased extracellular DNA secretion and altered biofilm formation.
Veterinary microbiology - 1 Mar 2020
Alwis Priyangi A, Treerat Puthayalai, Gong Lan, Deveson Lucas Deanna, Allwood Elizabeth M, Prescott Mark, Devenish Rodney J, Adler Ben, Boyce John D
Abstract excerpt
Two-component signal transduction systems (TCSTS) are abundant among prokaryotes and regulate important functions, including drug resistance and virulence. The Gram-negative bacterium Burkholderia pseudomallei, which causes the severe infectious disease melioidosis, encodes 136 putative TCSTS components. In silico analyses of these TCSTS indicated that the predicted BbeR-BbeS system (BPSL1036-BPSL1037) displayed...
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