Article
Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster.
PLoS neglected tropical diseases - 1 Jun 2017
Borlee Grace I, Plumley Brooke A, Martin Kevin H, Somprasong Nawarat, Mangalea Mihnea R, Islam M Nurul, Burtnick Mary N, Brett Paul J, Steinmetz Ivo, AuCoin David P, Belisle John T, Crick Dean C, Schweizer Herbert P, Borlee Bradley R
Abstract excerpt
Burkholderia pseudomallei, the causative agent of melioidosis, is an important public health threat due to limited therapeutic options for treatment. Efforts to improve therapeutics for B. pseudomallei infections are dependent on the need to understand the role of B. pseudomallei biofilm formation and its contribution to antibiotic tolerance and persistence as these are bacterial traits that prevent effective...
Topics
- Biofilms
- Burkholderia cenocepacia
- Burkholderia pseudomallei
- Comparative Genomic Hybridization
- Gene Expression Regulation, Bacterial
- Genome, Bacterial
- Multigene Family
- Mutation
- Polysaccharides, Bacterial