Article
Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei.
BMC genomics - 4 May 2016
Lazar Adler Natalie R, Allwood Elizabeth M, Deveson Lucas Deanna, Harrison Paul, Watts Stephen, Dimitropoulos Alexandra, Treerat Puthayalai, Alwis Priyangi, Devenish Rodney J, Prescott Mark, Govan Brenda, Adler Ben, Harper Marina, Boyce John D
Abstract excerpt
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis, a severe invasive disease of humans and animals. Initial screening of a B. pseudomallei signature-tagged mutagenesis library identified an attenuated mutant with a transposon insertion in a gene encoding the sensor component of an uncharacterised two-component signal transduction system (TCSTS), which we designated BprRS. RESULTS: Single...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.