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PRKC Fusion Melanocytic Tumors, a Subgroup of Melanocytic Tumors More Closely Aligned to Blue Nevi Than to PRKAR1A-inactivated Pigmented Epithelioid Melanocytomas.

The American journal of surgical pathology - 1 Nov 2024

Patel Pragi, Chen Alice, Sharma Natasha, Zhang Yongzhan, Quan Victor L, Olivares Shantel, Gerami Pedram

Abstract excerpt

Tumors morphologically classified as pigmented epithelioid melanocytomas (PEMs) are genomically diverse, with the 2 most common genomic subtypes being PRKC fusions or PRKAR1A inactivating mutations. PRKC fusions activate the Gα q/11 pathway similar to blue nevi. Conversely, inactivating mutations in PRKAR1A activate the Gα s pathway. We hypothesize that PRKC fusions have greater genomic overlap with blue nevi...

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PMID: 38864210
DOI: 10.1097/PAS.0000000000002262

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