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Article

Defects in long-chain 3-hydroxy acyl-CoA dehydrogenase lead to hepatocellular carcinoma: A novel etiology of hepatocellular carcinoma.

International journal of cancer - 1 Sept 2020

Khare Tripti, Khare Sharad, Angdisen Jerry J, Zhang Qiong, Stuckel Alexei, Mooney Brian P, Ridenhour Suzanne E, Gitan Raad S, Hammoud Ghassan M, Ibdah Jamal A

Abstract excerpt

The incidence of both nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) have been increasing at an alarming rate. Little is known about NAFLD without cirrhosis as a risk for HCC. Here we report, for the first time, generation of a mouse model with a defect in long-chain 3-hydoxy acyl-CoA dehydrogenase (LCHAD). The LCHAD exon 15 deletion was embryonic lethal to the homozygous mice whereas...

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Share to Acyl-CoA Dehydrogenase, Long-Chain
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32115688
DOI: 10.1002/ijc.32943

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