Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis.

Life sciences - 1 May 2020

Xiao Fei-Yan, Jiang Zhi-Ping, Yuan Fang, Zhou Fang-Jiao, Kuang Wei, Zhou Gan, Chen Xiao-Ping, Liu Rong, Zhou Hong-Hao, Zhao Xie-Lan, Cao Shan

Abstract excerpt

BACKGROUND: NQO1 protein acts as a cellular protective system, on account of its role as a quinone reductase and redox regulator. Nonetheless, new NQO1 roles are emerging-including its regulation of the cellular proliferation of many tumor cells-and this enzyme has been found to relate to the incidence of various diseases, including chronic myeloid leukemia. However, the mechanisms through which NQO1 influences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Topoisomerases, Type II
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterografts

Share to K562 Cells

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Leukocytes

Share to NAD(P)H Dehydrogenase (Quinone)

Share to Poly-ADP-Ribose Binding Proteins

Source

Identifiers

PMID: 32105706
DOI: 10.1016/j.lfs.2020.117467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulating NQO1 promotes cellular proliferation in K562 cells via elevating DNA synthesis.PMID 32105706Read ↗

Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults.Semantic proximity Read ↗

NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis.Semantic proximity Read ↗

DNA topoisomerase II, genotoxicity, and cancer.Semantic proximity Read ↗

Effects of the NQO1 609C>T polymorphism on leukemia susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Analysis of the C609T polymorphism of NQO1 gene in South Croatian patients with hematological malignancies.Semantic proximity Read ↗

Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family.Semantic proximity Read ↗

Down-regulation of DNA polymerases κ, η, ι, and ζ in human lung, stomach, and colorectal cancersSemantic proximity Read ↗

Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia.Semantic proximity Read ↗

Topoisomerase II and leukemiaSemantic proximity Read ↗

A meta-analysis of the association between NQO1 C609T variation and acute myeloid leukemia risk.Semantic proximity Read ↗

GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.Semantic proximity Read ↗

Gene Polymorphism of Xenobiotic Biotransformation Enzymes in Patients with Classical Ph-Negative Myeloproliferative Neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.