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Article

Inflammatory Phenotypes Predict Changes in Arterial Stiffness Following Antiretroviral Therapy Initiation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 3 Dec 2020

Kelly Christine, Tinago Willard, Alber Dagmar, Hunter Patricia, Luckhurst Natasha, Connolly Jake, Arrigoni Francesca, Abner Alejandro Garcia, Kamngona Ralph, Sheha Irene, Chammudzi Mishek, Jambo Kondwani, Mallewa Jane, Rapala Alicja, Heyderman Robert S, Mallon Patrick W G, Mwandumba Henry, Walker A Sarah, Klein Nigel, Khoo Saye

Abstract excerpt

BACKGROUND: Inflammation drives vascular dysfunction in HIV, but in low-income settings causes of inflammation are multiple, and include infectious and environmental factors. We hypothesized that patients with advanced immunosuppression could be stratified into inflammatory phenotypes that predicted changes in vascular dysfunction on ART. METHODS: We recruited Malawian adults with CD4 <100 cells/μL 2 weeks after...

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Biomarkers
CD8-Positive T-Lymphocytes
HIV Infections
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vascular Stiffness

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PMID: 32103268
DOI: 10.1093/cid/ciaa186
PMCID: PMC7713681

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