Article
Refining biomarker-based clustering of cardiovascular inflammatory phenotypes in HIV using Recursive Feature Addition: A comparative evaluation approach.
PLoS computational biology - 1 Apr 2026
Mac Cann Rachel, Alalwan Dana, Saini Gurvin, Garcia Leon Alejandro Abner, Kootstra Neeltje A, McGettrick Padraig, Cotter Aoife G, Winston Alan, Reiss Peter, Sabin Caroline, Mallon Patrick W
Abstract excerpt
BACKGROUND: People living with HIV remain at elevated risk for a number of non-communicable diseases, including cardiovascular disease (CVD), driven in part by chronic inflammation. While prior studies have identified inflammatory biomarker patterns linked to CVD in people with HIV, it remains unclear which combinations of biomarkers most effectively predict clinical outcomes. We aimed to develop and evaluate a...
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