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Article

Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth.

The Journal of experimental medicine - 4 May 2020

Francisco Michelle A, Wanggou Siyi, Fan Jerry J, Dong Weifan, Chen Xin, Momin Ali, Abeysundara Namal, Min Hyun-Kee, Chan Jade, McAdam Rochelle, Sia Marian, Pusong Ronwell J, Liu Shixuan, Patel Nish, Ramaswamy Vijay, Kijima Noriyuki, Wang Lu-Yang, Song Yuanquan, Kafri Ran, Taylor Michael D, Li Xuejun, Huang Xi

Abstract excerpt

Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) is overexpressed in human central nervous system malignancies, including medulloblastoma, a common pediatric brain cancer. While global knockout does not overtly affect mouse development, genetic deletion of CLIC1 suppresses medulloblastoma growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32097463
DOI: 10.1084/jem.20190971
PMCID: PMC7201926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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