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Article

Interactions between a Polygenic Risk Score and Non-genetic Risk Factors in Young-Onset Breast Cancer.

Scientific reports - 24 Feb 2020

Shi M, O'Brien K M, Weinberg C R

Abstract excerpt

Most gene-environmental studies have focused on breast cancers generally, the preponderance of which occur after age 50. Young-onset breast cancers (YOBC) tend to be aggressive and may be etiologically different. The goal of this analysis was to assess interactions between an established 77-SNP polygenic risk score (PRS) and non-genetic risk factors for YOBC. We constructed the PRS using a family-based study of...

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Identifiers

PMID: 32094468
DOI: 10.1038/s41598-020-60032-3
PMCID: PMC7039983

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