Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress

24 Feb 2020

Abstract excerpt

Multiple myeloma, the second most common hematologic malignancy, frequently relapses because of chemotherapeutic resistance. Fibroblast growth factors (FGF) act as proangiogenic and mitogenic cytokines in multiple myeloma. Here, we demonstrate that the autocrine FGF/FGFR axis is essential for multiple myeloma cell survival and progression by protecting multiple myeloma cells from oxidative stress-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor Research
Share to Histone Deacetylase Inhibitors Research
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32094301
DOI: 10.1158/0008-5472.can-19-2714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative StressPMID 32094301Read ↗

Ferroptosis Induction in Multiple Myeloma Cells Triggers DNA Methylation and Histone Modification Changes Associated with Cellular SenescenceSemantic proximity Read ↗

Alteration of mitochondrial biogenesis promotes disease progression in multiple myelomaSemantic proximity Read ↗

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive MyelomaSemantic proximity Read ↗

NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1Semantic proximity Read ↗

Autophagy and Apoptosis: Current Challenges of Treatment and Drug Resistance in Multiple MyelomaSemantic proximity Read ↗

Understanding DNA Damage Response and DNA Repair in Multiple MyelomaSemantic proximity Read ↗

DNA Damage Response in Multiple Myeloma: The Role of the Tumor MicroenvironmentSemantic proximity Read ↗

Comprehensive analysis of ferroptosis-related genes in immune infiltration and prognosis in multiple myelomaSemantic proximity Read ↗

Autophagy-related mechanisms for treatment of multiple myelomaSemantic proximity Read ↗

Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroupsSemantic proximity Read ↗

Myeloma and DNA damageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.