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Article

The Interplay Between Genetic Risk Factors and Proteolytic Dysregulation in the Pathophysiology of Inflammatory Bowel Disease.

Journal of Crohn's & colitis - 7 Sept 2020

Solà-Tapias Núria, Vergnolle Nathalie, Denadai-Souza Alexandre, Barreau Frédérick

Abstract excerpt

Crohn's disease [CD] and ulcerative colitis [UC] are the two main forms of inflammatory bowel disease [IBD]. Previous studies reported increased levels of proteolytic activity in stool and tissue samples from IBD patients, whereas the re-establishment of the proteolytic balance abrogates the development of experimental colitis. Furthermore, recent data suggest that IBD occurs in genetically predisposed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32090263
DOI: 10.1093/ecco-jcc/jjaa033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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