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Article

Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review.

PloS one - 1 Jan 2011

Cleynen Isabelle, Jüni Peter, Bekkering Geertruida E, Nüesch Eveline, Mendes Camila T, Schmied Stefanie, Wyder Stefan, Kellen Eliane, Villiger Peter M, Rutgeerts Paul, Vermeire Séverine, Lottaz Daniel

Abstract excerpt

As part of the European research consortium IBDase, we addressed the role of proteases and protease inhibitors (P/PIs) in inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation of the gastrointestinal tract, which affects 2.2 million people in Europe and 1.4 million people in North America. We systematically reviewed all published genetic studies on populations of European ancestry (67...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21931648
DOI: 10.1371/journal.pone.0024106
PMCID: PMC3169567

Genes

APEH
CYLD
DAG1
MST1
USP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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