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Article

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease.

Gut - 1 Aug 2014

Cleynen Isabelle, Vazeille Emilie, Artieda Marta, Verspaget Hein W, Szczypiorska Magdalena, Bringer Marie-Agnès, Lakatos Peter L, Seibold Frank, Parnell Kirstie, Weersma Rinse K, Mahachie John Jestinah M, Morgan-Walsh Rebecca, Staelens Dominiek, Arijs Ingrid, De Hertogh Gert, Müller Stefan, Tordai Atilla, Hommes Daniel W, Ahmad Tariq, Wijmenga Cisca, Pender Sylvia, Rutgeerts Paul, Van Steen Kristel, Lottaz Daniel, Vermeire Severine, Darfeuille-Michaud Arlette

Abstract excerpt

OBJECTIVE: Altered microbiota composition, changes in immune responses and impaired intestinal barrier functions are observed in IBD. Most of these features are controlled by proteases and their inhibitors to maintain gut homeostasis. Unrestrained or excessive proteolysis can lead to pathological...

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Topics

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Share to Bacterial Adhesion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deubiquitinating Enzyme CYLD

Share to Dystroglycans

Share to I-kappa B Proteins

Share to Peptide Hydrolases

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Source

Identifiers

PMID: 24092863
DOI: 10.1136/gutjnl-2012-303205

Genes

CYLD
APEH
USP3
USP40
DAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24092863-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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