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HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?

18 Feb 2020

Abstract excerpt

Human papillomavirus (HPV) E6 and E7 oncoproteins are critical for development and maintenance of the malignant phenotype in HPV-induced cancers. These two viral oncoproteins interfere with a plethora of cellular pathways, including the regulation of cell cycle and the control of apoptosis, which are critical in maintaining normal cellular functions. E6 and E7 bind directly with certain components of the...

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PMID: 32085533
DOI: 10.3390/pathogens9020133

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