Article
Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2013
Bernstein Jonine L, Thomas Duncan C, Shore Roy E, Robson Mark, Boice John D, Stovall Marilyn, Andersson Michael, Bernstein Leslie, Malone Kathleen E, Reiner Anne S, Lynch Charles F, Capanu Marinela, Smith Susan A, Tellhed Lina, Teraoka Sharon N, Begg Colin B, Olsen Jorgen H, Mellemkjaer Lene, Liang Xiaolin, Diep Anh T, Borg Ake, Concannon Patrick, Haile Robert W
Abstract excerpt
BACKGROUND: Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers....
Topics
- Adult
- BRCA1 Protein
- BRCA2 Protein
- Breast
- Breast Neoplasms
- Case-Control Studies
- Cohort Studies
- Female
- Genetic Predisposition to Disease