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Article

CRISPR/Cas9 engineering of albino cystinuria Type A mice.

Genesis (New York, N.Y. : 2000) - 1 May 2020

Beckermann Thomas M, Welch Richard C, Williams Felisha M, Mortlock Douglas P, Sha Feng, Ikizler Talat A, Woodard Lauren E, Wilson Matthew H

Abstract excerpt

Cystinuria Type A is a relatively common genetic kidney disease occurring in 1 in 7,000 people worldwide that results from mutation of the cystine transporter rBAT encoded by Slc3a1. We used CRISPR/Cas9 technology to engineer cystinuria Type A mice via genome editing of the C57BL/6NHsd background. These mice are an improvement on currently available models as they are on a coisogenic genetic background and have a...

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Identifiers

PMID: 32078250
DOI: 10.1002/dvg.23357
PMCID: PMC7781090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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