Article
Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.
Cardiovascular drugs and therapy - 1 Jun 2021
Morales-Rosado Joel A, Goel Kashish, Zhang Lingxin, Åkerblom Axel, Baheti Saurabh, Black John L, Eriksson Niclas, Wallentin Lars, James Stefan, Storey Robert F, Goodman Shaun G, Jenkins Gregory D, Eckloff Bruce W, Bielinski Suzette J, Sicotte Hugues, Johnson Stephen, Roger Veronique L, Wang Liewei, Weinshilboum Richard, Klee Eric W, Rihal Charanjit S, Pereira Naveen L
Abstract excerpt
PURPOSE: Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annotation and functional studies. METHODS: Seventy ST cases on clopidogrel identified from the PLATO trial (n = 58) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.