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Article

FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism.

Nature communications - 13 Feb 2020

Chen Xin, Ji Boyang, Hao Xinxin, Li Xiaowei, Eisele Frederik, Nyström Thomas, Petranovic Dina

Abstract excerpt

Alzheimer's disease (AD) is defined by progressive neurodegeneration, with oligomerization and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In recent years, the yeast Saccharomyces cerevisiae has been successfully used to clarify the roles of different human proteins involved in neurodegeneration. Here, we report a genome-wide synthetic genetic interaction array to identify...

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Identifiers

PMID: 32054832
DOI: 10.1038/s41467-020-14525-4
PMCID: PMC7018843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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