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Article

Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71.

Investigative ophthalmology & visual science - 7 Feb 2020

Barboni Mirella Telles Salgueiro, Vaillend Cyrille, Joachimsthaler Anneka, Liber André Maurício Passos, Khabou Hanen, Roux Michel J, Vacca Ophélie, Vignaud Lucile, Dalkara Deniz, Guillonneau Xavier, Ventura Dora Fix, Rendon Alvaro, Kremers Jan

Abstract excerpt

Purpose: To study the potential effect of a gene therapy, designed to rescue the expression of dystrophin Dp71 in the retinas of Dp71-null mice, on retinal physiology. Methods: We recorded electroretinograms (ERGs) in Dp71-null and wild-type littermate mice. In dark-adapted eyes, responses to flashes of several strengths were measured. In addition, flash responses on a 25-candela/square meters background were...

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Identifiers

PMID: 32049345
DOI: 10.1167/iovs.61.2.11
PMCID: PMC7326481

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