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Article

Long-term retinal cone rescue using a capsid mutant AAV8 vector in a mouse model of CNGA3-achromatopsia.

PloS one - 1 Jan 2017

Dai Xufeng, He Ying, Zhang Hua, Zhang Yangyang, Liu Yan, Wang Muran, Chen Hao, Pang Ji-Jing

Abstract excerpt

Adeno-associated virus (AAV) vectors are important gene delivery tools for the treatment of many recessively inherited retinal diseases. For example, a wild-type (WT) AAV5 vector can deliver a full-length Cnga3 (cyclic nucleotide-gated channel alpha-3) cDNA to target cells of the cone photoreceptor function loss 5 (cpfl5) mouse, a spontaneous animal model of achromatopsia with a Cnga3 mutation. Gene therapy...

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Source

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Identifiers

PMID: 29131863
DOI: 10.1371/journal.pone.0188032
PMCID: PMC5683625

Genes

CNGA3
ERG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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