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Article

Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease.

JAMA cardiology - 1 Apr 2020

Trinder Mark, Francis Gordon A, Brunham Liam R

Abstract excerpt

Importance: Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). However, many individuals with hypercholesterolemia have a polygenic rather than a monogenic cause for their condition. It is unclear if a genetic variant for hypercholesterolemia alters the risk of...

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Share to Coronary Artery Disease
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Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32049305
DOI: 10.1001/jamacardio.2019.5954
PMCID: PMC7042820

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