Article
Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia.
Atherosclerosis - 1 Aug 2017
Sharifi Mahtab, Higginson Elizabeth, Bos Sven, Gallivan Angela, Harvey Darren, Li Ka Wah, Abeysekera Amali, Haddon Angela, Ashby Helen, Shipman Kate E, Cooper Jackie A, Futema Marta, Roeters van Lennep Jeanine E, Sijbrands Eric J G, Labib Mourad, Nair Devaki, Humphries Steve E
Abstract excerpt
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes causing FH and are most likely to have a polygenic cause for their raised LDL-C. We assessed the...
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