Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations.

doi:10.3389/fimmu.2019.03097

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Article

Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations.

Frontiers in immunology - 1 Jan 2019

Świerzko Anna S, Michalski Mateusz, Sokołowska Anna, Nowicki Mateusz, Szala-Poździej Agnieszka, Eppa Łukasz, Mitrus Iwona, Szmigielska-Kapłon Anna, Sobczyk-Kruszelnicka Małgorzata, Michalak Katarzyna, Gołos Aleksandra, Wierzbowska Agnieszka, Giebel Sebastian, Jamroziak Krzysztof, Kowalski Marek L, Brzezińska Olga, Thiel Steffen, Matsushita Misao, Jensenius Jens C, Gajek Gabriela, Cedzyński Maciej

Abstract excerpt

A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted. Ficolins are innate immune defense factors, able to distinguish between "self" "abnormal self," and "non-self" and contribute to the elimination of the last two by direct opsonization and/or initiation...

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PMID: 32047495
DOI: 10.3389/fimmu.2019.03097
PMCID: PMC6997528

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