Article
Endothelial cells in the bone marrow of patients with multiple myeloma.
Blood - 1 Nov 2003
Vacca Angelo, Ria Roberto, Semeraro Fabrizio, Merchionne Francesca, Coluccia Mauro, Boccarelli Angela, Scavelli Claudio, Nico Beatrice, Gernone Angela, Battelli Feliciana, Tabilio Antonio, Guidolin Diego, Petrucci Maria Teresa, Ribatti Domenico, Dammacco Franco
Abstract excerpt
Endothelial cells (EC) were extracted through a lectin-based method from bone marrow of 57 patients with active multiple myeloma (MM) and compared with their healthy quiescent counterpart, human umbilical vein EC (HUVEC). MMECs exhibit specific antigens that indicate ongoing angiogenesis and embryo vasculogenesis; solid intercellular connections, hence stability of MM neovessels; and frequent interactions with...
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